Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.40 |
| ▸ | MEN1 | O00255 | 6/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8265491 | 0.90 | HTT (0.47) | HTTRAB9ALMNANPC1OPRM1 | |
| SCHEMBL8262945 | 0.84 | MAPT (0.47) | HTTF10KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8264462 | 0.78 | SMN1; SMN2 (0.44) | HTTRAB9ALMNANPC1F10 | |
| SCHEMBL8264033 | 0.77 | SMN1; SMN2 (0.44) | HTTRAB9ALMNANPC1F10 | |
| SCHEMBL8262948 | 0.75 | F10 (0.43) | HTTRAB9ANPC1F10KMT2A | |
| SCHEMBL3561007 | 0.74 | HTT (0.41) | HTTRAB9ALMNANPC1OPRM1 | |
| SCHEMBL8263562 | 0.74 | F7 (0.48) | HTTRAB9ANPC1F10KMT2A | |
| SCHEMBL8265206 | 0.74 | F7 (0.43) | HTTKMT2AMEN1SMN1; SMN2UTS2R | |
| SCHEMBL13439293 | 0.74 | F7 (0.43) | HTTKMT2AMEN1SMN1; SMN2UTS2R | |
| SCHEMBL8264048 | 0.73 | F10 (0.44) | HTTRAB9ALMNANPC1F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678913-B2 | Ureas as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-03-16 | — | — | US | disclosed |
| US-7678913-B2 | Ureas as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-03-16 | — | — | US | disclosed |
| WO-2006063113-A2 | UREAS AS FACTOR XA INHIBITORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2006-06-15 | — | — | WO | disclosed |