Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.81 |
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 7/20 | 0.60 |
| ▸ | RAB9A | P51151 | 9/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 7/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11673798 | 0.90 | MAPT (1.00) | MAPTNOX1GAARAB9AKMT2A | |
| SCHEMBL11673800 | 0.90 | MAPT (1.00) | MAPTNOX1GAARAB9AKMT2A | |
| SCHEMBL8265794 | 0.87 | MAPT (0.61) | MAPTNOX1GAARAB9AKMT2A | |
| SCHEMBL28937334 | 0.85 | MAPT (0.58) | MAPTNOX1GAARAB9AKMT2A | |
| SCHEMBL1729594 | 0.83 | NOX1 (0.69) | MAPTNOX1GAARAB9AKMT2A | |
| SCHEMBL6081637 | 0.83 | NOX1 (0.69) | MAPTNOX1GAARAB9AKMT2A | |
| SCHEMBL11545496 | 0.83 | MAPT (0.86) | MAPTNOX1GAARAB9AKMT2A | |
| SCHEMBL11545493 | 0.83 | MAPT (0.86) | MAPTNOX1GAARAB9AKMT2A | |
| SCHEMBL8265977 | 0.81 | MAPT (0.67) | MAPTGAARAB9AKMT2AMEN1 | |
| SCHEMBL11388177 | 0.81 | NOX1 (0.91) | MAPTNOX1GAARAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006029850-A1 | HYDRAZONE DERIVATIVES AND THEIR USE AS BETA SECRETASE INHIBITORS | THE GENETICS COMPANY, INC. (CH) | 2006-03-23 | — | — | WO | disclosed |