Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14350472 | 0.88 | BACE1 (0.30) | BACE1 | |
| SCHEMBL5648748 | 0.88 | BACE1 (0.40) | BACE1BACE2 | |
| SCHEMBL5648755 | 0.88 | BACE1 (0.40) | BACE1BACE2 | |
| SCHEMBL5648750 | 0.88 | BACE1 (0.40) | BACE1BACE2 | |
| SCHEMBL14350505 | 0.88 | BACE1 (0.46) | BACE1BACE2 | |
| SCHEMBL8265001 | 0.82 | BACE1 (0.45) | BACE1BACE2 | |
| SCHEMBL14350503 | 0.81 | BACE1 (0.43) | BACE1BACE2 | |
| SCHEMBL5651057 | 0.81 | BACE1 (0.46) | BACE1BACE2 | |
| SCHEMBL5651061 | 0.81 | BACE1 (0.46) | BACE1BACE2 | |
| SCHEMBL5651053 | 0.81 | BACE1 (0.46) | BACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1817311-B1 | 2,3,4,6-SUBSTITUTED PYRIDYL DERIVATIVE COMPOUNDS USEFUL AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME (US) | 2012-10-17 | — | — | EP | disclosed |
| WO-2006057945-A2 | 2,3,4,6-SUBSTITUTED PYRIDYL DERIVATIVE COMPOUNDS USEFUL AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERCK & CO., INC. (US) | 2006-06-01 | — | — | WO | disclosed |