Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14105052 | 0.99 | BACE1 (0.39) | BACE1ALDH1A1SMN1; SMN2LMNAMAPK1 | |
| SCHEMBL10305479 | 0.88 | BACE1 (0.41) | BACE1ALDH1A1SMN1; SMN2LMNAMAPK1 | |
| SCHEMBL8265240 | 0.80 | BACE1 (0.43) | BACE1ALDH1A1SMN1; SMN2LMNAMAPK1 | |
| SCHEMBL17550893 | 0.80 | BACE1 (0.44) | BACE1ALDH1A1SMN1; SMN2LMNANPC1 | |
| SCHEMBL7600289 | 0.80 | BACE1 (0.46) | BACE1NPC1RAB9A | |
| SCHEMBL14643202 | 0.79 | BACE1 (0.44) | BACE1SMN1; SMN2LMNAKMT2AMTOR | |
| SCHEMBL8265686 | 0.79 | BACE1 (0.61) | BACE1ALDH1A1SMN1; SMN2LMNAMAPK1 | |
| SCHEMBL7518723 | 0.79 | BACE1 (0.45) | BACE1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL7516202 | 0.79 | BACE1 (0.63) | BACE1 | |
| SCHEMBL14644350 | 0.79 | BACE1 (0.46) | BACE1SMN1; SMN2LMNAMTORNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838304-B1 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS | SCHERING CORP (US) | 2009-08-19 | — | — | EP | disclosed |
| WO-2008103351-A2 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS | SCHERING CORPORATION (US) | 2008-08-28 | — | — | WO | disclosed |
| WO-2006065277-A2 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS | SCHERING CORPORATION (US) | 2006-06-22 | — | — | WO | disclosed |