Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F7 | P08709 | 1/20 | 0.41 |
| ▸ | UTS2R | Q9UKP6 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
| ▸ | ULK1 | O75385 | 1/20 | 0.37 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | F10 | P00742 | 2/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CASR | P41180 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8262948 | 0.90 | F10 (0.43) | F7UTS2RMAPTS1PR4S1PR3 | |
| SCHEMBL8265206 | 0.90 | F7 (0.43) | F7UTS2RMAPTS1PR4S1PR3 | |
| SCHEMBL13439295 | 0.89 | F10 (0.46) | F7UTS2RMAPTS1PR4S1PR3 | |
| SCHEMBL13439296 | 0.87 | F7 (0.41) | F7UTS2RMAPTS1PR4S1PR3 | |
| SCHEMBL8264045 | 0.83 | F7 (0.45) | F7MAPTS1PR4S1PR3ULK1 | |
| SCHEMBL8262945 | 0.79 | MAPT (0.47) | F7UTS2RMAPTS1PR4S1PR3 | |
| SCHEMBL8264515 | 0.78 | F10 (0.45) | F7MAPTF10 | |
| SCHEMBL8264020 | 0.78 | F10 (0.43) | F7MAPTS1PR4S1PR3ALDH1A1 | |
| SCHEMBL8263562 | 0.76 | F7 (0.48) | F7UTS2RMAPTS1PR4S1PR3 | |
| SCHEMBL13439293 | 0.76 | F7 (0.43) | F7UTS2RMAPTS1PR4S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678913-B2 | Ureas as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-03-16 | — | — | US | disclosed |
| US-7678913-B2 | Ureas as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-03-16 | — | — | US | disclosed |
| WO-2006063113-A2 | UREAS AS FACTOR XA INHIBITORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2006-06-15 | — | — | WO | disclosed |