Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 2/20 | 0.66 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.66 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 4/20 | 0.41 |
| ▸ | CA1 | P00915 | 4/20 | 0.41 |
| ▸ | CA2 | P00918 | 4/20 | 0.41 |
| ▸ | CA4 | P22748 | 4/20 | 0.41 |
| ▸ | CA7 | P43166 | 4/20 | 0.41 |
| ▸ | CA9 | Q16790 | 4/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4223241 | 0.91 | GRM2 (0.68) | GRM2GRM3BCHEACHEBACE1 | |
| Hydrochloric Acid SCHEMBL4223247 | 0.91 | GRM2 (0.68) | GRM2GRM3BCHEACHEBACE1 | |
| SCHEMBL951814 | 0.88 | GRM2 (0.77) | GRM2GRM3BCHEACHEBACE1 | |
| SCHEMBL951812 | 0.88 | GRM2 (0.77) | GRM2GRM3BCHEACHEBACE1 | |
| SCHEMBL12946109 | 0.88 | GRM2 (0.64) | GRM2GRM3BCHEACHEBACE1 | |
| Hydrochloric Acid SCHEMBL4219537 | 0.87 | GRM2 (0.76) | GRM2GRM3BCHEACHEBACE1 | |
| Hydrochloric Acid SCHEMBL955690 | 0.87 | GRM2 (0.63) | GRM2GRM3BCHEACHEBACE1 | |
| Hydrochloric Acid SCHEMBL950974 | 0.87 | GRM2 (0.63) | GRM2GRM3BCHEACHEBACE1 | |
| Hydrochloric Acid SCHEMBL4219540 | 0.87 | GRM2 (0.76) | GRM2GRM3BCHEACHEBACE1 | |
| Hydrochloric Acid SCHEMBL951989 | 0.87 | GRM2 (0.63) | GRM2GRM3BCHEACHEBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006044454-A1 | 1-(HETERO)ARYL-3-AMINO-PYROLLIDINE DERIVATIVES FOR USE AS MGLUR3 RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2006-04-27 | — | — | WO | disclosed |