Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.77 |
| ▸ | RAB9A | P51151 | 7/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.77 |
| ▸ | HPGD | P15428 | 2/20 | 0.77 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | CASP3 | P42574 | 1/20 | 0.64 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.64 |
| ▸ | F10 | P00742 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.58 |
| ▸ | RELA | Q04206 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11433155 | 0.91 | NPC1 (0.93) | NPC1RAB9ASMN1; SMN2HPGDPOLB | |
| SCHEMBL10495055 | 0.88 | NPC1 (0.82) | NPC1RAB9ASMN1; SMN2HPGDPOLB | |
| SCHEMBL1578277 | 0.88 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2HPGDPOLB | |
| SCHEMBL11424416 | 0.88 | NPC1 (0.93) | NPC1RAB9ASMN1; SMN2HPGDPOLB | |
| SCHEMBL443363 | 0.87 | NPC1 (0.79) | NPC1RAB9ASMN1; SMN2HPGDPOLB | |
| SCHEMBL10354460 | 0.87 | NPC1 (0.79) | NPC1RAB9ASMN1; SMN2HPGDPOLB | |
| SCHEMBL12502477 | 0.84 | PARP10 (0.65) | NPC1RAB9ASMN1; SMN2HPGDPARP10 | |
| SCHEMBL448229 | 0.84 | NPC1 (0.75) | NPC1RAB9ASMN1; SMN2HPGDPOLB | |
| SCHEMBL2217897 | 0.84 | NPC1 (0.79) | NPC1RAB9ASMN1; SMN2HPGDPOLB | |
| SCHEMBL4500939 | 0.82 | NPC1 (0.82) | NPC1RAB9ASMN1; SMN2HPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006042035-A2 | METHOD OF MONITORING ANTI-TUMOR ACTIVITY OF AN HDAC INHIBITOR | PHARMACYCLICS, INC. (US) | 2006-04-20 | — | — | WO | disclosed |