Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4462270 | 0.90 | SMN1; SMN2 (0.52) | TP53SMN1; SMN2TSHRDRD4ALDH1A1 | |
| SCHEMBL4458570 | 0.89 | TP53 (0.49) | TP53SMN1; SMN2TSHRDRD4ALDH1A1 | |
| SCHEMBL8269420 | 0.89 | TP53 (0.47) | TP53SMN1; SMN2TSHRDRD4ALDH1A1 | |
| SCHEMBL27702523 | 0.84 | TP53 (0.49) | TP53SMN1; SMN2TSHRDRD4ALDH1A1 | |
| SCHEMBL4466954 | 0.83 | TP53 (0.48) | TP53SMN1; SMN2TSHRDRD4ALDH1A1 | |
| SCHEMBL8268614 | 0.82 | PDE4A (0.36) | TP53SMN1; SMN2ALDH1A1LMNAPOLB | |
| SCHEMBL4472360 | 0.82 | SMN1; SMN2 (0.53) | TP53SMN1; SMN2TSHRALDH1A1HPGD | |
| SCHEMBL4457771 | 0.82 | SMN1; SMN2 (0.53) | TP53SMN1; SMN2TSHRALDH1A1HPGD | |
| SCHEMBL4458851 | 0.82 | SMN1; SMN2 (0.53) | TP53SMN1; SMN2TSHRALDH1A1HPGD | |
| SCHEMBL4472346 | 0.79 | TP53 (0.47) | TP53SMN1; SMN2TSHRDRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006044955-A1 | PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2006-04-27 | — | — | WO | disclosed |