Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 11/20 | 0.58 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.58 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8270573 | 0.88 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL8315493 | 0.87 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL4824785 | 0.86 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL4824775 | 0.86 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8269944 | 0.84 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL8315305 | 0.84 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL8268727 | 0.80 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL17662314 | 0.79 | KMT2A (0.73) | KMT2ANPSR1L3MBTL1MAPTTSHR | |
| SCHEMBL8319800 | 0.78 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL13986036 | 0.77 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006026747-A2 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORPORATION (US) | 2006-03-09 | — | — | WO | disclosed |
| WO-2004078144-A2 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORPORATION (US) | 2004-09-16 | — | — | WO | disclosed |