Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 7/20 | 0.67 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.67 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.67 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.67 |
| ▸ | PARP1 | P09874 | 1/20 | 0.54 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.54 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.54 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.54 |
| ▸ | CES2 | O00748 | 1/20 | 0.53 |
| ▸ | CES1 | P23141 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
| ▸ | STS | P08842 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8269868 | 0.95 | PARP1 (0.59) | PDE4APDE4BPDE4CPDE4DPARP1 | |
| SCHEMBL8269310 | 0.89 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DPARP1 | |
| SCHEMBL8269853 | 0.89 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DPARP1 | |
| SCHEMBL8271372 | 0.88 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DPARP1 | |
| SCHEMBL8321025 | 0.87 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DABCG2 | |
| SCHEMBL8269329 | 0.84 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4DPARP1 | |
| SCHEMBL8271316 | 0.82 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DPRSS1 | |
| SCHEMBL8319800 | 0.80 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4825120 | 0.80 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPARP1 | |
| SCHEMBL4825122 | 0.80 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006026747-A2 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORPORATION (US) | 2006-03-09 | — | — | WO | disclosed |
| WO-2004078144-A2 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORPORATION (US) | 2004-09-16 | — | — | WO | disclosed |