Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.77 |
| ▸ | CTSD | P07339 | 2/20 | 0.77 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8269561 | 1.00 | BACE1 (0.77) | BACE1CTSDBACE2 | |
| SCHEMBL8269481 | 0.87 | BACE1 (1.00) | BACE1CTSDBACE2 | |
| SCHEMBL8269624 | 0.84 | BACE1 (0.68) | BACE1CTSDBACE2 | |
| SCHEMBL8269499 | 0.83 | BACE1 (0.86) | BACE1CTSDBACE2 | |
| SCHEMBL8269515 | 0.82 | BACE1 (0.83) | BACE1CTSDBACE2 | |
| SCHEMBL4493497 | 0.82 | BACE1 (0.73) | BACE1CTSDBACE2 | |
| SCHEMBL8269542 | 0.79 | BACE1 (1.00) | BACE1CTSDBACE2 | |
| SCHEMBL4480681 | 0.77 | BACE1 (0.74) | BACE1CTSDBACE2 | |
| SCHEMBL4494218 | 0.76 | BACE1 (0.73) | BACE1CTSDBACE2 | |
| SCHEMBL4468219 | 0.76 | BACE1 (0.74) | BACE1CTSDBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7488832-B2 | e.g. N-[amino(imino)methyl]-2-[2-(4-phenoxyphenyl)-5-phenyl-1H-pyrrol-1-yl]acetamide; beta -amyloid deposits and neurofibrillary tangles; cognition activator, neurodegenerative diseases; Alzheimer's disease, Down's syndrome | WYETH (US) | 2009-02-10 | — | — | US | disclosed |
| US-20080287424-A1 | AZOLYLACYLGUANIDINES AS beta-SECRETASE INHIBITORS | WYETH (US) | 2008-11-20 | — | — | US | disclosed |
| US-20060183790-A1 | Azolylacylguanidines as beta-secretase inhibitors | WYETH (US) | 2006-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287424-A1 | AZOLYLACYLGUANIDINES AS beta-SECRETASE INHIBITORS | BACE1, BACE2, APP | BACE1 1/4885CTSD 590/4885BACE2 2/4885 |
| US-20060183790-A1 | Azolylacylguanidines as beta-secretase inhibitors | BACE1, BACE2, APP | BACE1 1/4885CTSD 590/4885BACE2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.