Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.59 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.59 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.45 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.45 |
| ▸ | TUBB | P07437 | 2/20 | 0.45 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.45 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.45 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.45 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.45 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13986032 | 0.91 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DTUBB1 | |
| SCHEMBL8319883 | 0.89 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL8321041 | 0.85 | TUBB1 (0.64) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL8320626 | 0.83 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DABCG2 | |
| SCHEMBL8320594 | 0.83 | PDE4A (0.63) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL8269870 | 0.78 | TUBB1 (0.47) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL4822510 | 0.75 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8321025 | 0.74 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DABCG2 | |
| SCHEMBL8270323 | 0.73 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL8319800 | 0.73 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006026747-A2 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORPORATION (US) | 2006-03-09 | — | — | WO | disclosed |
| WO-2004078144-A2 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORPORATION (US) | 2004-09-16 | — | — | WO | disclosed |