Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | GBA1 | P04062 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.55 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.54 |
| ▸ | TOP2A | P11388 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8268365 | 0.94 | PDE5A (0.78) | PDE5ASMN1; SMN2HPGDPDE10AMAPT | |
| SCHEMBL8268880 | 0.92 | PDE5A (0.68) | PDE5ASMN1; SMN2HPGDMAPTKDM4E | |
| SCHEMBL8268376 | 0.90 | PDE10A (0.56) | PDE5APDE10AALDH1A1PIP4K2ATDP1 | |
| SCHEMBL8268379 | 0.87 | PDE5A (0.64) | PDE5ASMN1; SMN2PDE10AMAPTKDM4E | |
| SCHEMBL8269875 | 0.87 | PDE5A (0.78) | PDE5ASMN1; SMN2HPGDMAPTKDM4E | |
| SCHEMBL8270097 | 0.86 | PDE5A (0.67) | PDE5ASMN1; SMN2HPGDMAPTKDM4E | |
| SCHEMBL8268892 | 0.85 | PIP4K2A (0.59) | PDE5ASMN1; SMN2HPGDPDE10AMAPT | |
| SCHEMBL8268888 | 0.85 | PDE5A (0.75) | PDE5ASMN1; SMN2HPGDMAPTKDM4E | |
| SCHEMBL8268896 | 0.85 | PDE5A (0.64) | PDE5APDE10AALDH1A1PIP4K2ATOP2A | |
| SCHEMBL8269892 | 0.83 | PIP4K2A (0.53) | PDE5ASMN1; SMN2HPGDPDE10AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006034512-A2 | PHENYL-SUBSTITUTED QUINOLINE AND QUINAZOLINE COMPOUNDS FOR THE TREATMENT OF DIABETES | BAYER PHARMACEUTICALS CORPORATION (US) | 2006-03-30 | — | — | WO | disclosed |