Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 3/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 5/20 | 0.39 |
| ▸ | ABL1 | P00519 | 2/20 | 0.39 |
| ▸ | BCR | P11274 | 1/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.38 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.34 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2027146 | 0.91 | GRM2 (0.43) | GRM2CHRM5ABL1BCRKLKB1 | |
| SCHEMBL2021568 | 0.90 | GRM2 (0.53) | GRM2CHRM5ABL1BCRKLKB1 | |
| SCHEMBL2024184 | 0.83 | ABL1 (0.49) | GRM2CHRM5ABL1BCRCREBBP | |
| SCHEMBL2024101 | 0.82 | GRM2 (0.54) | GRM2CHRM5ABL1BCRKLKB1 | |
| SCHEMBL2023111 | 0.82 | GRM2 (0.51) | GRM2CHRM5ABL1BCRKLKB1 | |
| SCHEMBL2023172 | 0.79 | CREBBP (0.43) | GRM2CHRM5ABL1BCRCREBBP | |
| SCHEMBL2026154 | 0.78 | CHRM5 (0.49) | GRM2CHRM5ABL1ROCK2ROCK1 | |
| SCHEMBL2021289 | 0.78 | GRM2 (0.50) | GRM2CHRM5ABL1BCRKLKB1 | |
| SCHEMBL2024736 | 0.78 | ABL1 (0.45) | GRM2CHRM5ABL1BCRAADAT | |
| SCHEMBL2029579 | 0.77 | CYP3A4 (0.46) | CYP3A4CYP2C9CREBBPKCNH2IKBKE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006020879-A1 | ISOINDOLONE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | ASTRAZENECA AB (SE) | 2006-02-23 | — | — | WO | disclosed |