Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 20/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 17/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 11/20 | 0.60 |
| ▸ | CHRM1 | P11229 | 9/20 | 0.60 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.60 |
| ▸ | HTR2B | P41595 | 1/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.60 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL826965 | 0.94 | HRH1 (0.60) | HRH1CYP2D6KCNH2CHRM1ADRA2A | |
| SCHEMBL16881623 | 0.93 | HRH1 (0.59) | HRH1CYP2D6KCNH2CHRM1ADRA2A | |
| SCHEMBL12045389 | 0.92 | HRH1 (0.58) | HRH1CYP2D6KCNH2CHRM1ADRA2A | |
| SCHEMBL12045374 | 0.91 | HRH1 (0.67) | HRH1CYP2D6KCNH2CHRM1ADRA2A | |
| SCHEMBL12045361 | 0.89 | HRH1 (0.68) | HRH1CYP2D6KCNH2CHRM1ADRA2A | |
| SCHEMBL12045414 | 0.88 | HRH1 (0.66) | HRH1CYP2D6KCNH2CHRM1ADRA2A | |
| SCHEMBL12045379 | 0.88 | HRH1 (0.65) | HRH1CYP2D6KCNH2CHRM1ADRA2A | |
| SCHEMBL826746 | 0.88 | HRH1 (0.65) | HRH1CYP2D6KCNH2CHRM1ADRA2A | |
| SCHEMBL12045390 | 0.87 | HRH1 (0.69) | HRH1CYP2D6KCNH2CHRM1ADRA2A | |
| SCHEMBL826804 | 0.87 | HRH1 (0.69) | HRH1CYP2D6KCNH2CHRM1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011163594-A2 | PRODRUGS OF NH-ACIDIC COMPOUNDS: ESTER, CARBONATE, CARBAMATE AND PHOSPHONATE DERIVATIVES | ALKERMES, INC. (US) | 2011-12-29 | — | — | WO | disclosed |