Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 0.63 |
| ▸ | PDE11A | Q9HCR9 | 11/20 | 0.63 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13919777 | 0.95 | PDE4B (0.60) | PDE4BPDE11APDE10A | |
| SCHEMBL13919732 | 0.95 | PDE4B (0.60) | PDE4BPDE11APDE10A | |
| SCHEMBL13919638 | 0.91 | PDE4B (0.64) | PDE4BPDE11APDE10A | |
| SCHEMBL13919713 | 0.90 | PDE4B (0.69) | PDE4BPDE11APDE10A | |
| SCHEMBL13919870 | 0.89 | PDE4B (0.62) | PDE4BPDE11APDE10A | |
| SCHEMBL13919839 | 0.89 | PDE4B (0.62) | PDE4BPDE11APDE10A | |
| SCHEMBL13919868 | 0.89 | PDE4B (0.62) | PDE4BPDE11APDE10A | |
| SCHEMBL13919909 | 0.89 | PDE4B (0.62) | PDE4BPDE11APDE10A | |
| SCHEMBL13919878 | 0.89 | PDE4B (0.62) | PDE4BPDE11APDE10A | |
| SCHEMBL13920117 | 0.89 | PDE4B (0.62) | PDE4BPDE11A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7511062-B2 | Substituted 2-quinolyl-oxazoles useful as PDE4 inhibitors | SCHERING CORPORATION (US) | 2009-03-31 | — | — | US | disclosed |
| US-7511062-B2 | Substituted 2-quinolyl-oxazoles useful as PDE4 inhibitors | SCHERING CORPORATION (US) | 2009-03-31 | — | — | US | disclosed |
| WO-2005116009-A1 | SUBSTITUTED 2-QUINOLYL-OXAZOLES USEFUL AS PDE4 INHIBITORS | SCHERING CORPORATION (US) | 2005-12-08 | — | — | WO | disclosed |