Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 11/20 | 0.57 |
| ▸ | REN | P00797 | 1/20 | 0.51 |
| ▸ | CTSD | P07339 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | PDE4A | P27815 | 9/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3363134 | 0.89 | BACE1 (0.67) | BACE1RENCTSDKCNH2PDE4A | |
| SCHEMBL3365319 | 0.80 | BACE1 (0.74) | BACE1RENCTSDKCNH2PDE4A | |
| SCHEMBL2969383 | 0.78 | BACE1 (0.57) | BACE1RENCTSDKCNH2PDE4A | |
| SCHEMBL3363135 | 0.78 | BACE1 (0.54) | BACE1RENCTSDKCNH2PDE4A | |
| SCHEMBL8266799 | 0.78 | BACE1 (0.63) | BACE1RENCTSDKCNH2PDE4A | |
| SCHEMBL3367170 | 0.76 | BACE1 (0.59) | BACE1RENCTSDKCNH2PDE4A | |
| SCHEMBL5998529 | 0.74 | BACE1 (0.58) | BACE1RENCTSDKCNH2PDE4A | |
| SCHEMBL3361625 | 0.74 | BACE1 (0.57) | BACE1RENCTSDKCNH2 | |
| SCHEMBL8271266 | 0.74 | BACE1 (0.58) | BACE1RENCTSDKCNH2PDE4A | |
| SCHEMBL5999607 | 0.73 | BACE1 (1.00) | BACE1RENCTSDKCNH2PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006024932-A1 | 2-AMINO-QUINAZOLINE DERIVATIVES USEFUL AS INHIBITORS OF B-SECRETASE (BACE) | JANSSEN PHARMACEUTICA, N.V. (US) | 2006-03-09 | — | — | WO | disclosed |