Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 0.81 |
| ▸ | PDE11A | Q9HCR9 | 13/20 | 0.70 |
| ▸ | PDE10A | Q9Y233 | 9/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12162556 | 0.91 | PDE4B (0.68) | PDE4BPDE11APDE10A | |
| SCHEMBL8274575 | 0.90 | PDE4B (1.00) | PDE4BPDE11APDE10A | |
| SCHEMBL8276457 | 0.88 | PDE4B (1.00) | PDE4BPDE11APDE10A | |
| SCHEMBL8275056 | 0.87 | PDE4B (0.70) | PDE4BPDE11APDE10A | |
| SCHEMBL12162827 | 0.86 | PDE4B (0.82) | PDE4BPDE11APDE10A | |
| SCHEMBL12162562 | 0.84 | PDE4B (0.73) | PDE4BPDE11APDE10A | |
| SCHEMBL8274104 | 0.83 | PDE4B (0.76) | PDE4BPDE11APDE10A | |
| SCHEMBL8275108 | 0.83 | PDE4B (0.87) | PDE4BPDE11APDE10A | |
| SCHEMBL12162854 | 0.82 | PDE4B (0.76) | PDE4BPDE11APDE10A | |
| SCHEMBL12162980 | 0.82 | PDE4B (0.75) | PDE4BPDE11APDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005116009-A1 | SUBSTITUTED 2-QUINOLYL-OXAZOLES USEFUL AS PDE4 INHIBITORS | SCHERING CORPORATION (US) | 2005-12-08 | — | — | WO | disclosed |