Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 0.68 |
| ▸ | PDE11A | Q9HCR9 | 15/20 | 0.66 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.64 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12162578 | 0.93 | PDE4B (0.72) | PDE4BPDE11APDE10APDE4D | |
| SCHEMBL8274299 | 0.89 | PDE4B (0.66) | PDE4BPDE11A | |
| SCHEMBL12162887 | 0.85 | PDE4B (0.80) | PDE4BPDE11APDE10APDE4D | |
| SCHEMBL12163082 | 0.85 | PDE4B (0.76) | PDE4BPDE11APDE10APDE4D | |
| SCHEMBL13918608 | 0.84 | PDE4B (0.81) | PDE4BPDE11APDE10APDE4D | |
| SCHEMBL12163089 | 0.84 | PDE4B (0.75) | PDE4BPDE11APDE10APDE4D | |
| SCHEMBL12162816 | 0.84 | PDE4B (0.78) | PDE4BPDE11APDE10APDE4D | |
| SCHEMBL12162675 | 0.83 | PDE4B (0.80) | PDE4BPDE11APDE10APDE4D | |
| SCHEMBL13918607 | 0.83 | PDE4B (0.74) | PDE4BPDE11APDE10APDE4D | |
| SCHEMBL13918596 | 0.83 | PDE4B (0.74) | PDE4BPDE11APDE10APDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7511062-B2 | Substituted 2-quinolyl-oxazoles useful as PDE4 inhibitors | SCHERING CORPORATION (US) | 2009-03-31 | — | — | US | disclosed |
| US-7511062-B2 | Substituted 2-quinolyl-oxazoles useful as PDE4 inhibitors | SCHERING CORPORATION (US) | 2009-03-31 | — | — | US | disclosed |
| WO-2005116009-A1 | SUBSTITUTED 2-QUINOLYL-OXAZOLES USEFUL AS PDE4 INHIBITORS | SCHERING CORPORATION (US) | 2005-12-08 | — | — | WO | disclosed |