Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 20/20 | 0.75 |
| ▸ | GRM5 | P41594 | 6/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8276801 | 0.88 | GRM1 (0.75) | GRM1GRM5KDM4EALDH1A1HTT | |
| SCHEMBL8237274 | 0.88 | GRM1 (0.72) | GRM1GRM5KDM4E | |
| SCHEMBL8244777 | 0.88 | GRM1 (0.72) | GRM1GRM5KDM4E | |
| SCHEMBL8237281 | 0.88 | GRM1 (0.72) | GRM1GRM5KDM4EALDH1A1HPGD | |
| SCHEMBL8237296 | 0.86 | GRM1 (1.00) | GRM1GRM5KDM4EALDH1A1HPGD | |
| SCHEMBL8237942 | 0.86 | GRM1 (0.69) | GRM1GRM5KDM4E | |
| SCHEMBL8236754 | 0.86 | GRM1 (0.69) | GRM1GRM5KDM4EALDH1A1HTT | |
| SCHEMBL8242556 | 0.86 | GRM1 (0.78) | GRM1GRM5KDM4E | |
| SCHEMBL8237668 | 0.85 | GRM1 (0.73) | GRM1GRM5KDM4E | |
| SCHEMBL8246036 | 0.85 | GRM1 (0.74) | GRM1GRM5KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006002051-A1 | TRICYCLIC COMPOUNDS AND THEIR USE AS MGLUR1 ANTAGONISTS | SCHERING CORPORATION (US) | 2006-01-05 | — | — | WO | disclosed |