Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 5/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | HTR7 | P34969 | 2/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8281108 | 1.00 | PDE2A (0.41) | PDE2AHTR2AHTR2CHTR7RPS6KB1 | |
| SCHEMBL8282814 | 0.86 | PDE2A (0.41) | PDE2AHTR2AHTR2CHTR7RPS6KB1 | |
| SCHEMBL23231747 | 0.83 | PDE2A (0.45) | PDE2AHTR2AHTR2CHTR7DHODH | |
| SCHEMBL13451178 | 0.79 | PDE2A (0.41) | PDE2AHTR2AHTR2CHTR7RPS6KB1 | |
| SCHEMBL12021924 | 0.79 | PDE2A (0.45) | PDE2AHTR2AHTR2CHTR7RPS6KB1 | |
| SCHEMBL8418336 | 0.79 | PDE2A (0.45) | PDE2AHTR2AHTR2CHTR7DHODH | |
| SCHEMBL8220971 | 0.79 | PDE2A (0.41) | PDE2AHTR2AHTR2CHTR7DHODH | |
| SCHEMBL8258056 | 0.79 | PDE2A (0.45) | PDE2AHTR2AHTR2CHTR7DHODH | |
| SCHEMBL8226471 | 0.76 | PDE2A (0.43) | PDE2AHTR2AHTR2CHTR7DHODH | |
| SCHEMBL20446509 | 0.76 | SLC6A2 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1622912-B1 | 2-ALKYNYL-AND 2-ALKENYL-PYRAZOLO- [4,3-E ] -1,2,4-TRIAZOLO- [1,5-C] -PYRIMIDINE ADENOSINE A2A RECEPTOR ANTAGONISTS | SCHERING CORP (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2005103055-A1 | PYRAZOLO-[4,3-e]-1,2,4-TRIAZOLO-[1,5-c]-PYRIMIDINE ADENOSINE A2A RECEPTOR ANTAGONISTS | SCHERING CORPORATION (US) | 2005-11-03 | — | — | WO | disclosed |