Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 11/20 | 0.49 |
| ▸ | PSMB2 | P49721 | 6/20 | 0.49 |
| ▸ | PSMB1 | P20618 | 5/20 | 0.49 |
| ▸ | PSMB8 | P28062 | 5/20 | 0.49 |
| ▸ | PSMB10 | P40306 | 5/20 | 0.49 |
| ▸ | PSMB9 | P28065 | 5/20 | 0.49 |
| ▸ | PSMB11 | A5LHX3 | 4/20 | 0.49 |
| ▸ | PSMA7 | O14818 | 4/20 | 0.49 |
| ▸ | PSMA1 | P25786 | 4/20 | 0.49 |
| ▸ | PSMA2 | P25787 | 4/20 | 0.49 |
| ▸ | PSMA3 | P25788 | 4/20 | 0.49 |
| ▸ | PSMA4 | P25789 | 4/20 | 0.49 |
| ▸ | PSMA5 | P28066 | 4/20 | 0.49 |
| ▸ | PSMB4 | P28070 | 4/20 | 0.49 |
| ▸ | PSMB6 | P28072 | 4/20 | 0.49 |
| ▸ | PSMB3 | P49720 | 4/20 | 0.49 |
| ▸ | PSMA6 | P60900 | 4/20 | 0.49 |
| ▸ | PSMA8 | Q8TAA3 | 4/20 | 0.49 |
| ▸ | PSMB7 | Q99436 | 4/20 | 0.49 |
| ▸ | PSMD11 | O00231 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13557785 | 0.85 | ACE (0.48) | CTSBQRFPROPRD1OPRM1OPRK1 | |
| SCHEMBL8081495 | 0.84 | PSMB5 (0.69) | PSMB5PSMB2PSMB1PSMB8PSMB10 | |
| SCHEMBL12952611 | 0.84 | PSMB5 (0.69) | PSMB5PSMB2PSMB1PSMB8PSMB10 | |
| SCHEMBL22852888 | 0.84 | PSMB5 (0.58) | PSMB5PSMB2PSMB1PSMB8PSMB10 | |
| SCHEMBL8446152 | 0.84 | PSMB5 (0.58) | PSMB5PSMB2PSMB1PSMB8PSMB10 | |
| SCHEMBL8269345 | 0.84 | PSMB5 (0.45) | PSMB5PSMB2PSMB1PSMB8PSMB10 | |
| SCHEMBL23959803 | 0.84 | PSMB5 (0.48) | PSMB5PSMB2PSMB1PSMB8PSMB10 | |
| SCHEMBL23959826 | 0.82 | PSMB5 (0.47) | PSMB5PSMB2PSMB1PSMB8PSMB10 | |
| SCHEMBL13932371 | 0.81 | PSMB5 (0.51) | PSMB5PSMB2PSMB1PSMB8PSMB10 | |
| SCHEMBL2633254 | 0.80 | PSMB5 (0.73) | PSMB5PSMB2PSMB1PSMB8PSMB10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745064-B1 | COMPOUNDS FOR PROTEASOME ENZYME INHIBITION | PROTEOLIX INC (US) | 2011-01-05 | — | — | EP | disclosed |
| WO-2005105827-A2 | COMPOUNDS FOR PROTEASOME ENZYME INHIBITION | PROTEOLIX, INC. (US) | 2005-11-10 | — | — | WO | disclosed |