Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.63 |
| ▸ | FPR3 | P25089 | 4/20 | 0.46 |
| ▸ | FPR2 | P25090 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | BAZ2A | Q9UIF9 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2215321 | 0.86 | HRH3 (0.61) | HRH3MEN1KMT2ADHFREGFR | |
| SCHEMBL15650519 | 0.85 | HRH3 (0.60) | HRH3MEN1KMT2ADHFREGFR | |
| SCHEMBL1807775 | 0.84 | HRH3 (0.59) | HRH3MEN1KMT2ADHFREGFR | |
| SCHEMBL10425978 | 0.82 | HRH3 (0.57) | HRH3MAPTNPC1RAB9AMEN1 | |
| SCHEMBL3386166 | 0.78 | HRH3 (1.00) | HRH3MEN1KMT2A | |
| SCHEMBL13547516 | 0.73 | MAPT (0.53) | FPR3FPR2MAPTNPC1RAB9A | |
| SCHEMBL10425525 | 0.73 | HRH3 (0.47) | HRH3NPC1RAB9AMEN1KMT2A | |
| SCHEMBL15650902 | 0.72 | HRH3 (0.57) | HRH3DHFREGFRBAZ2AALOX15 | |
| SCHEMBL17177230 | 0.72 | HRH3 (0.46) | HRH3FPR3FPR2NPC1RAB9A | |
| SCHEMBL2642294 | 0.72 | MAPT (0.51) | FPR3FPR2MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005096734-A2 | NON-IMIDAZOLE HETEROCYCLIC COMPOUNDS AS HISTAMINE H3 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-10-20 | — | — | WO | disclosed |