Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 1/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.49 |
| ▸ | CLK1 | P49759 | 4/20 | 0.49 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.49 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.48 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | AXL | P30530 | 5/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.44 |
| ▸ | EGFR | P00533 | 3/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.44 |
| ▸ | FLT4 | P35916 | 3/20 | 0.44 |
| ▸ | FLT3 | P36888 | 3/20 | 0.44 |
| ▸ | CLK2 | P49760 | 3/20 | 0.44 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.44 |
| ▸ | CAMK2B | Q13554 | 3/20 | 0.44 |
| ▸ | CAMK2G | Q13555 | 3/20 | 0.44 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.44 |
| ▸ | PTK6 | Q13882 | 3/20 | 0.44 |
| ▸ | NTRK3 | Q16288 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8280111 | 0.87 | CDK8 (0.57) | CDK8DYRK1ACLK1DYRK1BDYRK2 | |
| SCHEMBL13356743 | 0.86 | CDK8 (0.54) | CDK8DYRK1ACLK1DYRK1BDYRK2 | |
| SCHEMBL8281301 | 0.85 | CDK8 (0.57) | CDK8DYRK1ACLK1DYRK1BDYRK2 | |
| SCHEMBL8280100 | 0.84 | CDK8 (0.56) | CDK8DYRK1ACLK1DYRK1BDYRK2 | |
| SCHEMBL2182230 | 0.82 | IGF1R (0.55) | CDK8DYRK1ACLK1DYRK1BDYRK2 | |
| SCHEMBL8280094 | 0.82 | CDK8 (0.56) | CDK8DYRK1ACLK1DYRK1BDYRK2 | |
| SCHEMBL8282410 | 0.81 | PTK2 (0.61) | CDK8DYRK1ACLK1DYRK1BDYRK2 | |
| SCHEMBL8281958 | 0.81 | IGF1R (0.69) | CDK8DYRK1ACLK1DYRK1BDYRK2 | |
| SCHEMBL8320344 | 0.80 | CDK8 (0.69) | CDK8IGF1RAXLNTRK1RIPK1 | |
| SCHEMBL8280097 | 0.80 | DYRK1B (0.49) | CDK8DYRK1ACLK1DYRK1BGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110166173-A1 | 3,5-DISUBSTUTUTED 1H-PYRROLO [2,3-B] PYRIDINES AS JNK INHIBITORS | EISAI CO., LTD. (JP) | 2011-07-07 | — | — | US | disclosed |
| US-20110166173-A1 | 3,5-DISUBSTUTUTED 1H-PYRROLO [2,3-B] PYRIDINES AS JNK INHIBITORS | EISAI CO., LTD. (JP) | 2011-07-07 | — | — | US | disclosed |
| EP-1720871-B1 | 3,5-DISUBSTITUTED 1H-PYRROLO [2,3-B] PYRIDINES AS JNK INHIBITORS | EISAI R&D MAN CO LTD (JP) | 2010-05-19 | — | — | EP | disclosed |
| WO-2005085244-A1 | 3,5-DISUBSTITUTED 1H-PZRROLO [2,3-B] PYRIDINES AS JNK INHIBITORS | EISAI LONDON RESEARCH LABORATORIES LIMITED (GB) | 2005-09-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166173-A1 | 3,5-DISUBSTUTUTED 1H-PYRROLO [2,3-B] PYRIDINES AS JNK INHIBITORS | API5, CDK5, MAPKAPK5 | CDK8 423/4885DYRK1A 911/4885CLK1 1193/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.