Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 13/20 | 0.93 |
| ▸ | ABL1 | P00519 | 11/20 | 0.93 |
| ▸ | BCR | P11274 | 8/20 | 0.93 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.93 |
| ▸ | EGFR | P00533 | 1/20 | 0.79 |
| ▸ | PRKCA | P17252 | 1/20 | 0.79 |
| ▸ | KIT | P10721 | 7/20 | 0.77 |
| ▸ | KDR | P35968 | 1/20 | 0.70 |
| ▸ | ABL2 | P42684 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9677 | 0.96 | PDGFRA (1.00) | PDGFRAABL1BCRPDGFRBEGFR | |
| SCHEMBL1656154 | 0.91 | PDGFRA (0.90) | PDGFRAABL1BCRPDGFRBEGFR | |
| SCHEMBL3219611 | 0.90 | PDGFRA (0.83) | PDGFRAABL1BCRPDGFRBEGFR | |
| SCHEMBL11932096 | 0.89 | PDGFRA (0.86) | PDGFRAABL1BCRPDGFRBEGFR | |
| SCHEMBL9820 | 0.89 | PDGFRA (1.00) | PDGFRAABL1BCRPDGFRBEGFR | |
| SCHEMBL3055349 | 0.88 | PDGFRA (0.89) | PDGFRAABL1BCRPDGFRBEGFR | |
| SCHEMBL13498211 | 0.88 | PDGFRA (0.88) | PDGFRAABL1BCRPDGFRBEGFR | |
| SCHEMBL9782 | 0.88 | PDGFRA (1.00) | PDGFRAABL1BCRPDGFRBEGFR | |
| SCHEMBL29498750 | 0.88 | PDGFRA (1.00) | PDGFRAABL1BCRPDGFRBEGFR | |
| SCHEMBL11927842 | 0.88 | ABL1 (1.00) | PDGFRAABL1BCRPDGFRBEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0564409-B1 | Pyrimidin derivatives and process for their preparation | NOVARTIS AG (CH) | 2000-01-19 | — | — | EP | disclosed |
| EP-0564409-A1 | Pyrimidin derivatives and process for their preparation | CIBA-GEIGY AG (CH) | 1993-10-06 | — | — | EP | disclosed |