Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 19/20 | 0.85 |
| ▸ | CTSD | P07339 | 16/20 | 0.85 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5669863 | 1.00 | BACE1 (0.85) | BACE1CTSDCYP3A4 | |
| SCHEMBL5734632 | 0.94 | BACE1 (0.74) | BACE1CTSD | |
| SCHEMBL8282585 | 0.93 | BACE1 (0.72) | BACE1CTSD | |
| SCHEMBL5666841 | 0.93 | BACE1 (0.72) | BACE1CTSD | |
| SCHEMBL5667251 | 0.92 | BACE1 (0.88) | BACE1CTSDCYP3A4 | |
| SCHEMBL8282604 | 0.92 | BACE1 (0.88) | BACE1CTSDCYP3A4 | |
| SCHEMBL3171968 | 0.91 | BACE1 (1.00) | BACE1CTSD | |
| SCHEMBL13315987 | 0.91 | BACE1 (1.00) | BACE1CTSD | |
| SCHEMBL3177992 | 0.91 | BACE1 (1.00) | BACE1CTSD | |
| SCHEMBL3168303 | 0.91 | BACE1 (1.00) | BACE1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005070407-A1 | METHODS OF TREATMENT OF AMYLOIDOSIS USING ASPARTYL-PROTEASE INIHIBITORS | ELAN PHARMACEUTICALS, INC. (US) | 2005-08-04 | — | — | WO | disclosed |