Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4423486 | 0.82 | SMN1; SMN2 (0.43) | GRM5ELANEALDH1A1MEN1KMT2A | |
| SCHEMBL14087386 | 0.80 | GRM5 (0.42) | GRM5ELANEMAOAMAOBL3MBTL1 | |
| SCHEMBL19152974 | 0.69 | GRM5 (0.48) | GRM5MAOAMAOBL3MBTL1KDM4E | |
| SCHEMBL17362213 | 0.69 | GRM5 (0.51) | GRM5L3MBTL1KDM4EALDH1A1TSHR | |
| SCHEMBL30558427 | 0.69 | GRM5 (0.51) | GRM5L3MBTL1KDM4EALDH1A1TSHR | |
| SCHEMBL4433345 | 0.68 | GRM5 (0.47) | GRM5ELANEMAOAMAOBKDM4E | |
| SCHEMBL24248023 | 0.68 | GRM5 (0.43) | GRM5ELANEMAOAMAOBL3MBTL1 | |
| SCHEMBL3894956 | 0.67 | CYP2C19 (0.54) | GRM5MAOAMAOBL3MBTL1KDM4E | |
| SCHEMBL4426496 | 0.66 | GRM5 (0.44) | GRM5MAOAMAOBTSHR | |
| SCHEMBL4432559 | 0.65 | CYP2C19 (0.52) | MAOAMAOBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005082856-A2 | TETRAHYDROQUINOLINONES AND THEIR USE AS ANTAGONISTS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2005-09-09 | — | — | WO | disclosed |