Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 17/20 | 0.64 |
| ▸ | HDAC8 | Q9BY41 | 14/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 13/20 | 0.64 |
| ▸ | HDAC4 | P56524 | 13/20 | 0.64 |
| ▸ | HDAC7 | Q8WUI4 | 13/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 13/20 | 0.64 |
| ▸ | HDAC10 | Q969S8 | 13/20 | 0.64 |
| ▸ | HDAC11 | Q96DB2 | 13/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 13/20 | 0.64 |
| ▸ | HDAC9 | Q9UKV0 | 13/20 | 0.64 |
| ▸ | HDAC5 | Q9UQL6 | 13/20 | 0.64 |
| ▸ | BRD4 | O60885 | 1/20 | 0.61 |
| ▸ | ESR1 | P03372 | 1/20 | 0.61 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.61 |
| ▸ | PDE4A | P27815 | 1/20 | 0.61 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.61 |
| ▸ | HTR6 | P50406 | 1/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.61 |
| ▸ | ASPH | Q12797 | 1/20 | 0.61 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1403367 | 0.87 | HDAC1 (0.69) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL1403365 | 0.87 | HDAC1 (0.69) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL1403252 | 0.78 | HDAC8 (1.00) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL1403249 | 0.78 | HDAC8 (1.00) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL1403105 | 0.78 | KMT2A (0.64) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL1403106 | 0.78 | KMT2A (0.64) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL1403258 | 0.78 | HDAC1 (1.00) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL1403256 | 0.78 | HDAC1 (1.00) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL1402938 | 0.77 | HDAC1 (0.72) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL1402937 | 0.77 | HDAC1 (0.72) | HDAC1HDAC8HDAC3HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005061448-A1 | COMPOSITIONS AND METHODS FOR TREATING VASCULAR CONDITIONS | MONASH UNIVERSITY (AU) | 2005-07-07 | — | — | WO | disclosed |
| WO-2005025557-A1 | AN AGENT FOR PLASMINOGEN-ACTIVATION AND MATRIX METALLOPROTEINASE ASSOCIATED CONDITIONS AND METHODS OF USE | MONASH UNIVERSITY (AU) | 2005-03-24 | — | — | WO | disclosed |