Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 9/20 | 0.59 |
| ▸ | CNR2 | P34972 | 5/20 | 0.44 |
| ▸ | DRD4 | P21917 | 4/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14203004 | 1.00 | SLC6A2 (0.59) | SLC6A2CNR2DRD4KCNH2DRD2 | |
| SCHEMBL5046485 | 1.00 | SLC6A2 (0.59) | SLC6A2CNR2DRD4KCNH2DRD2 | |
| SCHEMBL14202973 | 1.00 | SLC6A2 (0.59) | SLC6A2CNR2DRD4KCNH2DRD2 | |
| SCHEMBL14203046 | 0.90 | SLC6A2 (0.50) | SLC6A2CNR2DRD4DRD2DRD3 | |
| SCHEMBL14228800 | 0.90 | SLC6A2 (0.50) | SLC6A2CNR2DRD4DRD2DRD3 | |
| SCHEMBL5043853 | 0.90 | SLC6A2 (0.50) | SLC6A2CNR2DRD4DRD2DRD3 | |
| SCHEMBL14203097 | 0.88 | SLC6A2 (0.46) | SLC6A2CNR2DRD4KCNH2DRD2 | |
| SCHEMBL14228798 | 0.88 | SLC6A2 (0.46) | SLC6A2CNR2DRD4KCNH2DRD2 | |
| SCHEMBL5042305 | 0.87 | SLC6A2 (0.59) | SLC6A2CNR2DRD4DRD2DRD3 | |
| SCHEMBL14203009 | 0.87 | SLC6A2 (0.59) | SLC6A2CNR2DRD4DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005060949-A2 | SELECTIVE NOREPINEPHRINE REUPTAKE INHIBITORS FOR THE TREATMENT OF HOT FLASHES, IMPULSE CONTROL DISORDERS AND PERSONALITY CHANGE DUE TO A GENERAL MEDICAL CONDITION | ELI LILLY AND COMPANY (US) | 2005-07-07 | — | — | WO | disclosed |