Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 15/20 | 0.62 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4934815 | 0.90 | PDE4B (0.67) | PDE4BADORA1ADORA2A | |
| SCHEMBL4934833 | 0.90 | PDE4B (0.67) | PDE4BADORA1ADORA2A | |
| SCHEMBL4935532 | 0.90 | PDE4B (0.67) | PDE4BADORA1ADORA2A | |
| SCHEMBL8279447 | 0.86 | PDE4B (0.65) | PDE4BADORA1PDE4D | |
| SCHEMBL4937624 | 0.85 | PDE4B (0.80) | PDE4BADORA1 | |
| SCHEMBL4937633 | 0.85 | PDE4B (0.80) | PDE4BADORA1 | |
| SCHEMBL4938459 | 0.85 | PDE4B (0.80) | PDE4BADORA1 | |
| SCHEMBL583313 | 0.82 | PDE4B (0.70) | PDE4BADORA1ADORA2A | |
| SCHEMBL4928834 | 0.82 | PDE4B (0.78) | PDE4BPDE4D | |
| SCHEMBL4931660 | 0.81 | PDE4B (0.63) | PDE4BADORA1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005058892-A1 | PYRAZOLO [3,4-B] PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2005-06-30 | — | — | WO | disclosed |