Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | WEE1 | P30291 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | VCP | P55072 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287366 | 0.88 | PDE11A (0.57) | PDE11AMEN1KMT2AWEE1GSK3B | |
| SCHEMBL5871867 | 0.86 | PDE11A (0.54) | PDE11AMEN1KMT2AWEE1CNR1 | |
| SCHEMBL7042467 | 0.86 | PDE11A (0.60) | PDE11AMEN1KMT2AWEE1GSK3B | |
| SCHEMBL8287191 | 0.83 | PDE11A (0.59) | PDE11AMEN1KMT2AWEE1MAPT | |
| SCHEMBL5871955 | 0.83 | PDE11A (0.56) | PDE11AMEN1KMT2AWEE1MAPT | |
| SCHEMBL5871578 | 0.83 | PDE11A (0.58) | PDE11AMEN1KMT2AMAPTCNR1 | |
| SCHEMBL8287186 | 0.83 | PDE11A (0.58) | PDE11AMEN1KMT2AWEE1GSK3B | |
| SCHEMBL8286352 | 0.82 | PDE11A (0.60) | PDE11AMEN1KMT2AWEE1GSK3B | |
| SCHEMBL8286360 | 0.82 | PDE11A (0.55) | PDE11AMEN1KMT2AMAPTCNR1 | |
| SCHEMBL8360285 | 0.82 | PDE11A (0.59) | PDE11AMEN1KMT2AWEE1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |