Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 5/20 | 0.35 |
| ▸ | GSK3B | P49841 | 3/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 2/20 | 0.34 |
| ▸ | CCND1 | P24385 | 2/20 | 0.34 |
| ▸ | CCND2 | P30279 | 2/20 | 0.34 |
| ▸ | CCND3 | P30281 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | WEE1 | P30291 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287158 | 0.87 | PDE11A (0.41) | PDE11AGAAGSK3BCSF1RCDK4 | |
| SCHEMBL8286060 | 0.86 | PDE11A (0.46) | PDE11AGAAGSK3BCSF1RCDK4 | |
| SCHEMBL8287202 | 0.85 | PDE11A (0.39) | PDE11AGAAGSK3BCSF1RCDK4 | |
| SCHEMBL8287378 | 0.83 | PDE11A (0.38) | PDE11AGAAGSK3BCSF1RCDK4 | |
| SCHEMBL5872117 | 0.83 | PDE11A (0.43) | PDE11AGAAGSK3BCSF1RCDK4 | |
| SCHEMBL8285162 | 0.83 | PDE11A (0.43) | PDE11AGAAGSK3BCSF1RCDK4 | |
| SCHEMBL8287376 | 0.82 | PDE11A (0.37) | PDE11AGAAGSK3BCSF1RCDK4 | |
| SCHEMBL8287159 | 0.81 | PDE11A (0.38) | PDE11AGAAGSK3BCSF1R | |
| SCHEMBL8285170 | 0.81 | PDE11A (0.46) | PDE11AGAAGSK3BCSF1RCDK4 | |
| SCHEMBL8285168 | 0.81 | PDE11A (0.42) | PDE11AGAAGSK3BCSF1RCDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |