Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8285246 | 0.94 | PDE11A (0.39) | PDE11AGRM5PDE10ACYP1A2CYP3A4 | |
| SCHEMBL8285255 | 0.89 | MAPT (0.40) | PDE11AGRM5CYP1A2CYP3A4MEN1 | |
| SCHEMBL8285259 | 0.86 | PDE11A (0.37) | PDE11AGRM5PDE10AALDH1A1KDM4E | |
| SCHEMBL8285286 | 0.82 | GRM5 (0.36) | PDE11AGRM5PDE10AMAPTCDK4 | |
| SCHEMBL8287865 | 0.80 | FEN1 (0.43) | PDE11AALDH1A1TSHRMAPTKDM4E | |
| SCHEMBL8287874 | 0.78 | PDE11A (0.40) | PDE11AMEN1ALDH1A1KMT2AMAPT | |
| SCHEMBL8287877 | 0.77 | PDE11A (0.39) | PDE11AALDH1A1MAPTKDM4ENPC1 | |
| SCHEMBL8287866 | 0.77 | CYP3A4 (0.39) | PDE11ACYP1A2CYP3A4MEN1ALDH1A1 | |
| SCHEMBL5872004 | 0.76 | CYP1A2 (0.43) | PDE11AGRM5CYP1A2CYP3A4MEN1 | |
| SCHEMBL8286453 | 0.75 | GSK3B (0.35) | PDE11AGRM5CYP1A2CYP3A4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |