Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | WEE1 | P30291 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 12/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 11/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | CCND2 | P30279 | 1/20 | 0.34 |
| ▸ | CCND3 | P30281 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287101 | 0.91 | PDE11A (0.60) | PDE11AWEE1HCRTR1HCRTR2 | |
| SCHEMBL8287155 | 0.90 | PDE11A (0.59) | PDE11AMEN1LMNAKMT2AWEE1 | |
| SCHEMBL8286350 | 0.89 | PDE11A (0.58) | PDE11AMEN1LMNAKMT2AWEE1 | |
| SCHEMBL8287215 | 0.89 | PDE11A (0.61) | PDE11AHCRTR1HCRTR2 | |
| SCHEMBL8286353 | 0.89 | PDE11A (0.57) | PDE11AMEN1LMNAKMT2AWEE1 | |
| SCHEMBL8286351 | 0.88 | PDE11A (0.59) | PDE11AMEN1LMNAKMT2AWEE1 | |
| SCHEMBL8287224 | 0.87 | PDE11A (0.58) | PDE11AHCRTR1HCRTR2 | |
| SCHEMBL8287171 | 0.87 | PDE11A (0.56) | PDE11ALMNAWEE1HCRTR1HCRTR2 | |
| SCHEMBL8287148 | 0.87 | PDE11A (0.62) | PDE11AMEN1LMNAKMT2AWEE1 | |
| SCHEMBL8287174 | 0.85 | PDE11A (0.58) | PDE11AMEN1LMNAKMT2AWEE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |