Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 7/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8285149 | 0.91 | PDE11A (0.47) | PDE11ATDP1L3MBTL1MAPTLMNA | |
| SCHEMBL8287471 | 0.88 | PDE11A (0.45) | PDE11ATDP1L3MBTL1MAPTLMNA | |
| SCHEMBL8286439 | 0.88 | MAPT (0.52) | PDE11ATDP1L3MBTL1MAPTLMNA | |
| SCHEMBL8286434 | 0.87 | PDE11A (0.44) | PDE11ATDP1L3MBTL1MAPTLMNA | |
| SCHEMBL8287425 | 0.85 | PDE11A (0.43) | PDE11ATDP1L3MBTL1MAPTLMNA | |
| SCHEMBL8286414 | 0.85 | CSF1R (0.47) | PDE11ATDP1L3MBTL1MAPTPDE4B | |
| SCHEMBL8287397 | 0.85 | PDE11A (0.46) | PDE11AMAPTPDE4BPDE4APDE4C | |
| SCHEMBL8286440 | 0.84 | PDE11A (0.48) | PDE11ATDP1MAPTLMNAPOLB | |
| SCHEMBL8287154 | 0.84 | PDE11A (0.48) | PDE11ATDP1MAPTLMNAPOLB | |
| SCHEMBL8285163 | 0.84 | POLB (0.50) | PDE11ATDP1MAPTLMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |