SCHEMBL8288241

SCHEMBL8288241

NC1CNC(C(=O)N2CCCC2B(O)O)C1

nearest known ligand 0.64

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 20/20 0.64
DPP9 Q86TI2 14/20 0.61
DPP8 Q6V1X1 13/20 0.61
FAP Q12884 11/20 0.61
DPP7 Q9UHL4 11/20 0.61
PITRM1 Q5JRX3 5/20 0.53
PREP P48147 4/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13417319 1.00 DPP4 (0.64) DPP4DPP9DPP8FAPDPP7
SCHEMBL8288237 1.00 DPP4 (0.64) DPP4DPP9DPP8FAPDPP7
SCHEMBL13417322 1.00 DPP4 (0.64) DPP4DPP9DPP8FAPDPP7
SCHEMBL13347232 1.00 DPP4 (0.64) DPP4DPP9DPP8FAPDPP7
SCHEMBL13347234 1.00 DPP4 (0.64) DPP4DPP9DPP8FAPDPP7
SCHEMBL13417269 0.84 DPP4 (0.66) DPP4DPP9DPP8FAPDPP7
SCHEMBL13347200 0.84 DPP4 (0.66) DPP4DPP9DPP8FAPDPP7
SCHEMBL8287929 0.84 DPP4 (0.66) DPP4DPP9DPP8FAPDPP7
SCHEMBL13034870 0.83 DPP4 (0.64) DPP4DPP9DPP8FAPDPP7
SCHEMBL24322709 0.76 DPP4 (1.00) DPP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100120661-A1 HETEROCYCLIC BORONIC ACID COMPOUNDS PHENOMIX CORPORATION (US) 2010-05-13 US disclosed
US-7674913-B2 Heterocyclic boronic acid compounds PHENOMIX CORPORATION (US) 2010-03-09 US disclosed
EP-1997533-A1 Heterocyclic boronic acid compounds, dipeptidyl peptidase IV inhibitors Phenomix Corporation (US) 2008-12-03 EP disclosed
WO-2005047297-A1 HETEROCYCLIC BORONIC ACID COMPOUNDS PHENOMIX CORPORATION (US) 2005-05-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100120661-A1 HETEROCYCLIC BORONIC ACID COMPOUNDS DPP4, DPP7, DPP3 DPP4 1/4885DPP9 7/4885DPP8 4/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.