Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA2 | P42262 | 18/20 | 0.54 |
| ▸ | GRIA4 | P48058 | 18/20 | 0.54 |
| ▸ | FNTA | P49354 | 2/20 | 0.42 |
| ▸ | FNTB | P49356 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8288342 | 0.90 | GRIA2 (0.56) | GRIA2GRIA4FNTAFNTB | |
| SCHEMBL4375935 | 0.89 | GRIA2 (0.57) | GRIA2GRIA4 | |
| SCHEMBL8289417 | 0.87 | GRIA4 (0.69) | GRIA2GRIA4 | |
| SCHEMBL4372260 | 0.86 | GRIA2 (0.60) | GRIA2GRIA4FNTAFNTB | |
| SCHEMBL8289837 | 0.86 | GRIA4 (0.60) | GRIA2GRIA4 | |
| SCHEMBL4371272 | 0.85 | GRIA2 (0.58) | GRIA2GRIA4 | |
| SCHEMBL8288380 | 0.85 | GRIA2 (0.58) | GRIA2GRIA4FNTAFNTB | |
| SCHEMBL4373189 | 0.85 | GRIA2 (0.49) | GRIA2GRIA4FNTAFNTB | |
| SCHEMBL8288334 | 0.84 | GRIA2 (0.55) | GRIA2GRIA4FNTAFNTB | |
| SCHEMBL4381903 | 0.84 | GRIA2 (0.62) | GRIA2GRIA4FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670757-B1 | PYRROLE AND PYRAZOLE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | LILLY CO ELI (US) | 2009-05-06 | — | — | EP | disclosed |
| WO-2005040110-A1 | PYRROLE AND PYRAZOLE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2005-05-06 | — | — | WO | disclosed |