Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 15/20 | 0.59 |
| ▸ | GRIA2 | P42262 | 13/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287321 | 0.90 | GRIA4 (0.59) | GRIA4GRIA2ALDH1A1KDM4EHTT | |
| SCHEMBL8288356 | 0.90 | GRIA4 (0.60) | GRIA4GRIA2ALDH1A1KDM4EHPGD | |
| SCHEMBL8288360 | 0.89 | GRIA4 (0.59) | GRIA4GRIA2ALDH1A1KDM4EHPGD | |
| SCHEMBL8288318 | 0.88 | GRIA4 (0.77) | GRIA4GRIA2 | |
| SCHEMBL8288354 | 0.87 | GRIA4 (0.56) | GRIA4GRIA2ALDH1A1KDM4EHPGD | |
| SCHEMBL8289591 | 0.85 | GRIA4 (0.72) | GRIA4GRIA2 | |
| SCHEMBL4372491 | 0.81 | GRIA4 (0.61) | GRIA4GRIA2ALDH1A1KDM4EHPGD | |
| SCHEMBL8288396 | 0.80 | GRIA4 (0.59) | GRIA4GRIA2ALDH1A1KDM4EHPGD | |
| SCHEMBL8289793 | 0.80 | GRIA2 (0.77) | GRIA4GRIA2ALDH1A1KDM4EHPGD | |
| SCHEMBL8289331 | 0.79 | GRIA2 (0.51) | GRIA4GRIA2ALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670757-B1 | PYRROLE AND PYRAZOLE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | LILLY CO ELI (US) | 2009-05-06 | — | — | EP | disclosed |
| WO-2005040110-A1 | PYRROLE AND PYRAZOLE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2005-05-06 | — | — | WO | disclosed |