Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 11/20 | 0.60 |
| ▸ | GRIA2 | P42262 | 9/20 | 0.57 |
| ▸ | FNTA | P49354 | 7/20 | 0.51 |
| ▸ | FNTB | P49356 | 7/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4378785 | 0.89 | GRIA4 (0.73) | GRIA4GRIA2ALDH1A1L3MBTL1HTT | |
| SCHEMBL8288361 | 0.88 | GRIA4 (0.78) | GRIA4GRIA2ALDH1A1L3MBTL1HTT | |
| SCHEMBL4378375 | 0.87 | GRIA4 (0.73) | GRIA4GRIA2ALDH1A1L3MBTL1HTT | |
| SCHEMBL8288481 | 0.85 | GRIA4 (0.77) | GRIA4GRIA2 | |
| SCHEMBL8287317 | 0.82 | GRIA4 (0.72) | GRIA4GRIA2ALDH1A1L3MBTL1HTT | |
| SCHEMBL8288354 | 0.82 | GRIA4 (0.56) | GRIA4GRIA2ALDH1A1L3MBTL1HTT | |
| SCHEMBL20626561 | 0.82 | GRIA4 (0.56) | GRIA4GRIA2ALDH1A1L3MBTL1HTT | |
| SCHEMBL4372732 | 0.82 | GRIA4 (0.76) | GRIA4GRIA2 | |
| SCHEMBL8288390 | 0.82 | GRIA4 (0.56) | GRIA4GRIA2ALDH1A1L3MBTL1HTT | |
| SCHEMBL8289338 | 0.80 | GRIA4 (0.59) | GRIA4GRIA2ALDH1A1L3MBTL1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670757-B1 | PYRROLE AND PYRAZOLE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | LILLY CO ELI (US) | 2009-05-06 | — | — | EP | disclosed |
| WO-2005040110-A1 | PYRROLE AND PYRAZOLE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2005-05-06 | — | — | WO | disclosed |