Sugi Predict

Sugi Predict / Compounds / SCHEMBL8288777

SCHEMBL8288777

SCHEMBL8288777

CCOc1cc(C(CN)N2C(=O)c3cccc(NC(C)=O)c3C2=O)ccc1OC

nearest known ligand 0.85

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ PDE4B Q07343 20/20 0.85
▸ PDE4C Q08493 19/20 0.85
▸ PDE4A P27815 13/20 0.85
▸ PDE4D Q08499 13/20 0.85
▸ HTR2B P41595 1/20 0.80

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8269358 0.94 PDE4B (0.75) PDE4BPDE4CPDE4APDE4DHTR2B
SCHEMBL537699 0.92 PDE4B (0.90) PDE4BPDE4CPDE4APDE4DHTR2B
SCHEMBL537033 0.92 PDE4B (0.90) PDE4BPDE4CPDE4APDE4DHTR2B
SCHEMBL537255 0.92 PDE4B (0.90) PDE4BPDE4CPDE4APDE4DHTR2B
SCHEMBL23392623 0.90 PDE4B (0.87) PDE4BPDE4CPDE4APDE4DHTR2B
SCHEMBL21494457 0.90 PDE4B (0.87) PDE4BPDE4CPDE4APDE4DHTR2B
SCHEMBL21494501 0.90 PDE4B (0.87) PDE4BPDE4CPDE4APDE4DHTR2B
SCHEMBL18575797 0.90 PDE4B (0.81) PDE4BPDE4CPDE4APDE4DHTR2B
SCHEMBL18790415 0.90 PDE4B (0.81) PDE4BPDE4CPDE4APDE4DHTR2B
SCHEMBL3131846 0.90 PDE4B (0.87) PDE4BPDE4CPDE4APDE4DHTR2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005046592-A2 METHODS OF USING AND COMPOSITIONS COMPRISING PDE4 MODULATORS FOR THE TREATMENT AND MANAGEMENT OF ASBESTOS-RELATED DISEASES AND DISORDERS CELGENE CORPORATION (US) 2005-05-26 — — WO disclosed