Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.71 |
| ▸ | HPGD | P15428 | 2/20 | 0.71 |
| ▸ | MAPT | P10636 | 2/20 | 0.71 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.71 |
| ▸ | NPC1 | O15118 | 1/20 | 0.71 |
| ▸ | LMNA | P02545 | 1/20 | 0.71 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.71 |
| ▸ | RAB9A | P51151 | 1/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.71 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.71 |
| ▸ | JAK2 | O60674 | 2/20 | 0.66 |
| ▸ | IKBKB | O14920 | 1/20 | 0.66 |
| ▸ | JAK3 | P52333 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7003615 | 0.81 | JAK2 (0.63) | NPC1RAB9ASMN1; SMN2JAK2IKBKB | |
| SCHEMBL1385889 | 0.80 | JAK2 (1.00) | KMT2AMEN1JAK2IKBKBJAK3 | |
| SCHEMBL6614249 | 0.78 | JAK2 (0.78) | JAK2IKBKBJAK3 | |
| SCHEMBL5898695 | 0.78 | JAK2 (0.78) | ALOX15JAK2IKBKBJAK3 | |
| SCHEMBL7004222 | 0.78 | JAK2 (0.69) | JAK2IKBKBJAK3 | |
| SCHEMBL6999366 | 0.78 | JAK2 (0.69) | JAK2IKBKBJAK3 | |
| SCHEMBL17318556 | 0.77 | JAK2 (0.67) | MAPK10JAK2IKBKBJAK3 | |
| SCHEMBL7004367 | 0.77 | KDR (0.70) | MAPTNPC1RAB9ANPSR1JAK2 | |
| SCHEMBL6996032 | 0.76 | JAK2 (0.66) | KDM4EMAPTNPC1RAB9ANPSR1 | |
| SCHEMBL17318541 | 0.76 | KDR (0.69) | MAPTNPC1RAB9ANPSR1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015187827-A1 | NOVEL EFFECTIVE ANTIVIRAL COMPOUNDS AND METHODS USING SAME | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2015-12-10 | — | — | WO | disclosed |
| WO-2005033102-A2 | THIOPHENE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMPHORA DISCOVERY CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |