Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.67 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.67 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.67 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.62 |
| ▸ | NPC1 | O15118 | 3/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.62 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | AIP | O00170 | 1/20 | 0.56 |
| ▸ | SGTA | O43765 | 1/20 | 0.56 |
| ▸ | TOMM70 | O94826 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8289480 | 0.88 | MAPT (0.61) | MAPTDUSP3PTPN5PTPN11POLB | |
| SCHEMBL8289709 | 0.85 | MAPT (0.69) | MAPTDUSP3PTPN5PTPN11POLB | |
| SCHEMBL5447380 | 0.84 | MAPT (0.72) | MAPTDUSP3PTPN5PTPN11POLB | |
| SCHEMBL8289822 | 0.84 | MAPT (0.68) | MAPTDUSP3PTPN5PTPN11POLB | |
| SCHEMBL8288676 | 0.83 | MAPT (0.66) | MAPTDUSP3PTPN5PTPN11POLB | |
| SCHEMBL5453560 | 0.83 | POLB (0.67) | MAPTDUSP3PTPN5PTPN11POLB | |
| SCHEMBL3916246 | 0.83 | MAPT (0.78) | MAPTDUSP3PTPN5PTPN11POLB | |
| SCHEMBL5462746 | 0.82 | MAPT (0.69) | MAPTDUSP3PTPN5PTPN11POLB | |
| SCHEMBL13574989 | 0.82 | MAPT (0.72) | MAPTDUSP3PTPN5PTPN11POLB | |
| SCHEMBL8290418 | 0.82 | MAPT (0.65) | MAPTDUSP3PTPN5PTPN11POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005033102-A2 | THIOPHENE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMPHORA DISCOVERY CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |