Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA2 | P42262 | 18/20 | 0.77 |
| ▸ | GRIA4 | P48058 | 18/20 | 0.77 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8289872 | 0.91 | GRIA4 (0.69) | GRIA2GRIA4 | |
| SCHEMBL8289439 | 0.91 | GRIA4 (0.73) | GRIA2GRIA4 | |
| SCHEMBL8289785 | 0.89 | GRIA2 (0.60) | GRIA2GRIA4NR4A2MAOB | |
| SCHEMBL8287414 | 0.89 | GRIA4 (0.85) | GRIA2GRIA4 | |
| SCHEMBL8289454 | 0.87 | GRIA4 (1.00) | GRIA2GRIA4 | |
| SCHEMBL4373560 | 0.84 | GRIA4 (0.70) | GRIA2GRIA4 | |
| SCHEMBL8289849 | 0.83 | GRIA4 (0.77) | GRIA2GRIA4 | |
| SCHEMBL8289599 | 0.82 | GRIA4 (0.71) | GRIA2GRIA4 | |
| SCHEMBL8287421 | 0.82 | GRIA4 (1.00) | GRIA2GRIA4 | |
| SCHEMBL8287544 | 0.82 | GRIA4 (0.72) | GRIA2GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670757-B1 | PYRROLE AND PYRAZOLE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | LILLY CO ELI (US) | 2009-05-06 | — | — | EP | disclosed |
| WO-2005040110-A1 | PYRROLE AND PYRAZOLE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2005-05-06 | — | — | WO | disclosed |