SCHEMBL8290405

SCHEMBL8290405

COc1ccc(C(=O)Nc2sc3c(c2C(N)=O)CCCC3)cc1OC

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
FLT3 P36888 15/20 1.00
KMT2A Q03164 3/20 1.00
MEN1 O00255 2/20 1.00
RECQL P46063 1/20 1.00
TP53 P04637 1/20 0.74
MAPT P10636 1/20 0.74
RAB9A P51151 1/20 0.69
KDM4E B2RXH2 1/20 0.66
ALDH1A1 P00352 1/20 0.66
POLB P06746 1/20 0.66
HPGD P15428 1/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29766887 1.00 FLT3 (1.00) FLT3KMT2AMEN1RECQLTP53
SCHEMBL22095967 0.99 FLT3 (1.00) FLT3KMT2AMEN1RECQLTP53
SCHEMBL30148150 0.98 FLT3 (1.00) FLT3KMT2AMEN1RECQLTP53
SCHEMBL24425732 0.98 FLT3 (1.00) FLT3KMT2AMEN1RECQLTP53
SCHEMBL20704813 0.89 FLT3 (0.80) FLT3KMT2AMEN1RECQLMAPT
SCHEMBL8289827 0.87 KMT2A (0.82) FLT3KMT2AMEN1RECQLRAB9A
SCHEMBL3923796 0.86 MAPT (0.98) FLT3KMT2AMEN1RECQLTP53
SCHEMBL8290377 0.85 FLT3 (1.00) FLT3KMT2AMEN1RECQLTP53
SCHEMBL4138685 0.83 MAPT (0.75) FLT3KMT2AMEN1RECQLMAPT
SCHEMBL8290852 0.83 FLT3 (0.75) FLT3KMT2AMEN1RECQLMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10941382-B2 Platelet production promoter and method of producing platelets using same KYOTO UNIVERSITY (JP) 2021-03-09 US claimed
EP-3453759-B1 PLATELET PRODUCTION PROMOTER AND METHOD OF PRODUCING PLATELETS USING SAME UNIV KYOTO (JP) 2023-08-30 EP disclosed
WO-2023122577-A2 METHODS OF TREATING CANCER USING LIPOSOMAL PARTICLES COMPRISING ANTICANCER AGENTS AND PHARMACEUTICAL COMPOSITIONS RELATED THERETO EMORY UNIVERSITY (US) 2023-06-29 WO disclosed
US-10941382-B2 Platelet production promoter and method of producing platelets using same KYOTO UNIVERSITY (JP) 2021-03-09 US disclosed
US-20190032015-A1 Platelet Production Promoter and Method of Producing Platelets Using Same KYOTO UNIVERSITY (JP) 2019-01-31 US disclosed
WO-2005033102-A2 THIOPHENE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF AMPHORA DISCOVERY CORPORATION (US) 2005-04-14 WO disclosed