Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.66 |
| ▸ | FLT3 | P36888 | 3/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | PTPRC | P08575 | 1/20 | 0.58 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.58 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.58 |
| ▸ | PTPRB | P23467 | 1/20 | 0.58 |
| ▸ | PTPRE | P23469 | 1/20 | 0.58 |
| ▸ | CNR2 | P34972 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.49 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5449075 | 0.89 | CFTR (0.66) | CFTRKDM4EFLT3MEN1CYP1A2 | |
| SCHEMBL5458508 | 0.87 | CFTR (0.61) | CFTRKDM4EFLT3MEN1CYP1A2 | |
| SCHEMBL5447630 | 0.87 | CFTR (0.61) | CFTRKDM4EFLT3MEN1CYP1A2 | |
| SCHEMBL5445117 | 0.86 | PTPRC (0.65) | CFTRKDM4EFLT3MEN1CYP1A2 | |
| SCHEMBL5455876 | 0.86 | CFTR (0.60) | CFTRKDM4EFLT3MEN1CYP1A2 | |
| SCHEMBL5455880 | 0.86 | CFTR (0.60) | CFTRKDM4EFLT3MEN1CYP1A2 | |
| SCHEMBL5453381 | 0.85 | CFTR (0.66) | CFTRKDM4EFLT3MEN1CYP1A2 | |
| SCHEMBL5445049 | 0.85 | CFTR (0.60) | CFTRKDM4EFLT3MEN1CYP1A2 | |
| SCHEMBL5467520 | 0.85 | ANO1 (0.67) | CFTRKDM4EFLT3MEN1CYP1A2 | |
| SCHEMBL5455685 | 0.85 | CFTR (0.63) | CFTRKDM4EFLT3MEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005033102-A2 | THIOPHENE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMPHORA DISCOVERY CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |