Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMA1 | P23946 | 17/20 | 0.62 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.44 |
| ▸ | CTSG | P08311 | 1/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.44 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8290020 | 0.91 | CMA1 (0.64) | CMA1PRSS1PRSS2CTSGPRSS3 | |
| SCHEMBL999891 | 0.90 | CMA1 (0.76) | CMA1PRSS1PRSS2CTSGPRSS3 | |
| SCHEMBL999889 | 0.90 | CMA1 (0.76) | CMA1PRSS1PRSS2CTSGPRSS3 | |
| SCHEMBL12314992 | 0.87 | CMA1 (0.82) | CMA1PRSS1PRSS2CTSGPRSS3 | |
| SCHEMBL12315027 | 0.84 | CMA1 (0.71) | CMA1PRSS1PRSS2CTSGPRSS3 | |
| SCHEMBL3650587 | 0.83 | CMA1 (0.79) | CMA1PRSS1PRSS2CTSGPRSS3 | |
| SCHEMBL3650590 | 0.83 | CMA1 (0.79) | CMA1PRSS1PRSS2CTSGPRSS3 | |
| SCHEMBL4136294 | 0.83 | CMA1 (0.73) | CMA1PRSS1PRSS2CTSGPRSS3 | |
| SCHEMBL4136305 | 0.83 | CMA1 (0.73) | CMA1PRSS1PRSS2CTSGPRSS3 | |
| SCHEMBL3657627 | 0.82 | CMA1 (0.77) | CMA1PRSS1PRSS2CTSGPRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716160-B1 | NOVEL INHIBITORS OF CHYMASE | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-29 | — | — | EP | disclosed |
| WO-2005073214-A2 | NOVEL INHIBITORS OF CHYMASE | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-08-11 | — | — | WO | disclosed |