Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMA1 | P23946 | 15/20 | 0.62 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.53 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.53 |
| ▸ | CTSG | P08311 | 1/20 | 0.53 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.53 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12315022 | 0.93 | CMA1 (0.57) | CMA1PRSS1PRSS2CTSGPRSS3 | |
| SCHEMBL12315021 | 0.85 | CMA1 (0.59) | CMA1PRSS1PRSS2CTSGPRSS3 | |
| SCHEMBL12314981 | 0.85 | CMA1 (0.57) | CMA1PRSS1PRSS2CTSGPRSS3 | |
| SCHEMBL12314971 | 0.84 | CMA1 (0.56) | CMA1PRSS1PRSS2CTSGPRSS3 | |
| SCHEMBL12314973 | 0.83 | CMA1 (0.53) | CMA1PRSS1PRSS2CTSGPRSS3 | |
| SCHEMBL10331333 | 0.80 | CMA1 (0.54) | CMA1PRSS1PRSS2CTSGPRSS3 | |
| SCHEMBL1083297 | 0.78 | CMA1 (0.89) | CMA1PRSS1PRSS2CTSGPRSS3 | |
| SCHEMBL1083299 | 0.78 | CMA1 (0.89) | CMA1PRSS1PRSS2CTSGPRSS3 | |
| SCHEMBL1083298 | 0.78 | CMA1 (0.53) | CMA1PRSS1PRSS2CTSGPRSS3 | |
| SCHEMBL1001215 | 0.78 | CMA1 (1.00) | CMA1PRSS1PRSS2CTSGPRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716160-B1 | NOVEL INHIBITORS OF CHYMASE | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-29 | — | — | EP | disclosed |
| WO-2005073214-A2 | NOVEL INHIBITORS OF CHYMASE | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-08-11 | — | — | WO | disclosed |