Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMA1 | P23946 | 17/20 | 0.70 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.42 |
| ▸ | CTSG | P08311 | 1/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1050992 | 0.90 | CMA1 (0.86) | CMA1PRSS1PRSS2CTSGPRSS3 | |
| SCHEMBL1050990 | 0.90 | CMA1 (0.86) | CMA1PRSS1PRSS2CTSGPRSS3 | |
| SCHEMBL1001756 | 0.88 | CMA1 (0.80) | CMA1PRSS1PRSS2CTSGPRSS3 | |
| SCHEMBL1001749 | 0.88 | CMA1 (0.80) | CMA1PRSS1PRSS2CTSGPRSS3 | |
| SCHEMBL12315027 | 0.87 | CMA1 (0.71) | CMA1PRSS1PRSS2CTSGPRSS3 | |
| SCHEMBL12314992 | 0.86 | CMA1 (0.82) | CMA1PRSS1PRSS2CTSGPRSS3 | |
| SCHEMBL8290020 | 0.83 | CMA1 (0.64) | CMA1PRSS1PRSS2CTSGPRSS3 | |
| SCHEMBL13008686 | 0.83 | CMA1 (0.86) | CMA1PRSS1PRSS2CTSGPRSS3 | |
| SCHEMBL3651044 | 0.83 | CMA1 (1.00) | CMA1PRSS1PRSS2CTSGPRSS3 | |
| SCHEMBL3651051 | 0.83 | CMA1 (1.00) | CMA1PRSS1PRSS2CTSGPRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005073214-A2 | NOVEL INHIBITORS OF CHYMASE | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-08-11 | — | — | WO | disclosed |