Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 13/20 | 0.65 |
| ▸ | HDAC2 | Q92769 | 12/20 | 0.65 |
| ▸ | HDAC3 | O15379 | 12/20 | 0.63 |
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.63 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.61 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.58 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.56 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14244596 | 0.83 | HDAC8 (0.90) | HDAC8HDAC2HDAC3HDAC6HDAC1 | |
| SCHEMBL12425759 | 0.83 | HDAC8 (0.90) | HDAC8HDAC2HDAC3HDAC6HDAC1 | |
| SCHEMBL18495463 | 0.81 | HDAC8 (0.65) | HDAC8HDAC2HDAC3HDAC6HDAC1 | |
| SCHEMBL8256427 | 0.81 | HDAC3 (0.68) | HDAC8HDAC2HDAC3HDAC6HDAC1 | |
| SCHEMBL6865934 | 0.81 | HDAC8 (0.65) | HDAC8HDAC2HDAC3HDAC6HDAC1 | |
| SCHEMBL11101567 | 0.81 | HCAR2 (0.59) | HDAC8HDAC2HDAC3HDAC6HDAC1 | |
| SCHEMBL11101569 | 0.81 | HCAR2 (0.59) | HDAC8HDAC2HDAC3HDAC6HDAC1 | |
| SCHEMBL16806936 | 0.79 | HDAC8 (0.67) | HDAC8HDAC2HDAC3HDAC6HDAC1 | |
| SCHEMBL3292397 | 0.79 | HDAC2 (1.00) | HDAC8HDAC2HDAC3HDAC6HDAC1 | |
| SCHEMBL13762663 | 0.79 | HDAC8 (0.77) | HDAC8HDAC2HDAC3HDAC6HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005040101-A1 | ACYLUREA CONNECTED AND SULFONYLUREA CONNECTED HYDROXAMATES | S*BIO PTE LTD (SG) | 2005-05-06 | — | — | WO | disclosed |