Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.36 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.36 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.36 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | LYN | P07948 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | MARK3 | P27448 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8290957 | 0.79 | DYRK1A (0.38) | ROCK2ROCK1DYRK1ACLK4STK17A | |
| SCHEMBL8290740 | 0.78 | AXL (0.47) | ROCK2ROCK1DYRK1ACLK4STK17A | |
| SCHEMBL8290014 | 0.76 | AXL (0.46) | ROCK2ROCK1DYRK1ACLK4STK17A | |
| SCHEMBL8291655 | 0.74 | AXL (0.46) | ROCK2ROCK1DYRK1ACLK4STK17A | |
| SCHEMBL8291656 | 0.74 | AXL (0.44) | ROCK2ROCK1DYRK1ACLK4STK17A | |
| SCHEMBL8291658 | 0.74 | CDK8 (0.45) | ROCK2ROCK1DYRK1ACLK4STK17A | |
| SCHEMBL8291633 | 0.73 | CYP2C9 (0.44) | ROCK2ROCK1DYRK1ACLK4STK17A | |
| SCHEMBL8291646 | 0.72 | AXL (0.45) | ROCK2ROCK1DYRK1ACLK4STK17A | |
| SCHEMBL8290790 | 0.72 | DYRK1A (0.46) | ROCK2ROCK1DYRK1ACLK4STK17A | |
| SCHEMBL8290012 | 0.72 | CHEK1 (0.44) | DYRK1ACDK1ITGB2ICAM1ITGAL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005028475-A2 | COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2005-03-31 | — | — | WO | disclosed |